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鍥介檯椤剁骇鏈熷垔銆奊UT銆嬪彂琛ㄥ崕灞卞尰闄㈠紶缁ф槑鏁欐巿鍥㈤槦鑱斿悎鐮旂┒鎴愭灉

  鏃堕棿锛?020-07-02   鏉ユ簮锛氶檮灞炲崕灞卞尰闄↑/td>   鐐瑰嚮锛?97
 



杩戞棩锛屽鏃﹀ぇ瀛﹂檮灞炲崕灞卞尰闄㈡劅鏌撶寮犵户鏄庢暀鎺堝洟闃熴€佸竷鏈楀ぇ瀛﹁倽鐥呯爺绌朵腑蹇僑huping Tong銆丣isu Li鏁欐巿鍥㈤槦鍜屽帵闂ㄥぇ瀛﹀瀹侀偟銆佽鏉冩暀鎺堝洟闃熼壌瀹氬嚭涓€鏍珮鎰熸煋鎬鍩哄洜鍨婞/span>涔欏瀷鑲濈値鐥呮瘨锛圏/span>HBV锛堻/span>涓村簥鍒嗙鏍紝骞惰繘涓€姝ョ爺绌堕珮鎰熸煋鎬ф満鍒讹紝鎺㈢储鍏迭/span>涓村簥鎰忎箟銆傜浉鍏虫垚鏋滀互鈥淣aturally occurring 5鈥 preS1 deletions markedly enhance replication and infectivity of HBV genotype B and genotype C鈥濅负棰樺湪绾垮彂琛ㄤ簬鍥介檯钁楀悕鏈熷垔銆夵/span>GUT銆婞/span>銆侟/span>

楂樻晥鐨凕/span>HBV浣撳鎰熸煋妯″瀷瀵逛簬鐮旂┒HBV涓庡涓荤殑鐩镐簰浣滅敤绛夎嚦鍏抽噸瑕併€傜幇鏈変綋澶栨劅鏌撶粏鑳炴ā鍨嬩富瑕佹湁浜哄師浠h倽缁嗚優銆佸垎鍖栫殑HepaRG缁嗚優銆佸婧愭€ц〃杈近/span>NTCP鐨勮倽鐧岀粏鑳炵郴绛夛紝琚箍娉涘簲鐢ㄤ簬HBV鎰熸煋瀹為獙锛屼絾鍏辨湁涓嶈冻涔嬪鏄?/span>鎰熸煋鏁堢巼鍧囪緝浣庛€侟/span>鍦ㄧ梾姣掓潵婧愭柟闈紝鐢ㄤ簬浣撳鎰熸煋鐨勭梾姣掍富瑕佹潵鑷簬HepG2.2.15銆?/span>HepAD38鍜孅/span>HepDE19绛夌ǔ瀹氳浆鏌撶粏鑳濣/span>绯讳骇鐢熺殑D鍩哄洜鍨婞/span>HBV锛岃€屼腑鍥戒互B鍜孅/span>C鍩哄洜鍨嬫瘨鏍祦琛屼负涓汇€侟/span>鐩墠灏氱己涔廃/span>鍙綋澶栭珮鏁堟劅鏌撶殑B鎴朇鍩哄洜鍨嬫ā鍨嬫瘨鏍€侟/span>

璇?/span>鐮旂┒浠庝竴渚婞/span>鈥滃厤鐤€愬彈鏈熲€滭/span>鐨凕/span>C鍩哄洜鍨婞/span>HBV鎱㈡€ф劅鏌撹€匋/span>琛€娓呬腑鍒嗙鍑裹/span>5鈥欑preS1鍖裹/span>15 nt鍜孅/span>18 nt缂哄け绐佸彉鏍?/span>锛屽垎鏋愯鎮h€匋/span>2012骞淬€?/span>2017骞村拰2019骞寸殑绯诲垪琛€娓匋/span>鏍囨湰鍚庡彂鐜扮己澶包/span>鏍?/span>姣斾緥閫愭笎澧炲姞銆傜敤鐩稿悓鎷疯礉鏁?/span>鐥呮瘨鎰熸煋HepG2/NTCP鍜孒epaRG涓ょ缁嗚優锛屽彂鐜扮己澶辨牚鎰熸煋鎬у己浜庨噹鐢熸牚锛汓/span>鐩稿弽锛屽彟澶栦袱鏍嚜鐒跺彂鐢烖/span>5鈥欑preS1鍖虹己澶辩殑C鍩哄洜鍨婞/span>姣掓牚锛堝垎绂讳簬鎱箼鑲濊倽鐧屾偅鑰咃級涓噸鏂版彃鍏ヨ鍖裹/span>18 nt鐗囨銆佷互鍙奃鍩哄洜鍨嬪厠闅咟/span>璇?/span>鍖烘彃鍏?/span>33 nt鐗囨鍚庯紝鎰熸煋鎬у潎鏄庢樉涓嬮檷銆傞殢鍚庯紝鐮旂┒鑰呭彂鐜颁粎绐佸彉C鍩哄洜鍨媝reS1鍖虹涓€涓捣濮嬪瘑鐮佸瓙锛屼娇涔嬬炕璇戜骇鐢熺被浼间簬D鍩哄洜鍨嬨€佹埅鐭簡11涓皑鍩洪吀鐨凕/span>L铔嬬櫧瓒充互澧炲己鎰熸煋鎬?/span>銆備负楠岃瘉鎴煭鍨婰铔嬬櫧涓庢劅鏌撴€у寮烘湁鍏颤/span>锛岀爺绌惰€呭悎鎴愰噹鐢熷瀷鍜岀己澶卞瀷涓ょ璞嗚敾閰板寲淇グ鐨刾reS1澶氳偨锛屽彂鐜扮己澶卞瀷澶氳偨浣撳鎶戝埗HBV鎰熸煋鍙夵/span>涓嶩epG2/NTCP缁嗚優缁撳悎鑳藉姏鏇村己銆侟/span>鍚屾椂锛岀己澶包/span>鏍?/span>鎰熸煋鍚庢棭鏈熻優鍐卌ccDNA姘村钩鏄庢樉澧炲己銆備互涓婄粨鏋淈/span>鎻愮ず缂哄け鍨嬬梾姣掓劅鏌撹繘鍏ョ粏鑳炵殑鑳藉姏鏇村己锛孅/span>鍏舵満鍒迭/span>涓庢埅鐭?/span>鍨婞/span>L铔嬬櫧缁撳悎缁嗚優鐨勮兘鍔涙洿寮烘湁鍏炽€傛澶栵紝鐮旂┒鑰呯敤HBV 1.1鍊嶄綋杞煋HepG2缁嗚優锛孅/span>鍙戠幇18 nt缂哄け鏍浆鏌撳悗鑳炲唴HBV RNA銆丠BV DNA浠ュ強鑳濣/span>澶朁/span>鐥呮瘨棰楃矑閲婃斁姘村钩鍧囨槑鏄惧己浜嶞/span>閲庣敓鏍?/span>銆侟/span>


5鈥欑preS1鍖裹span>缂哄け鎴栨彃鍏ュHBV鎰熸煋鎬х殑褰卞搷



閲庣敓鍨嬪拰N绔埅鐭瀷preS1澶氳偨鎶戝埗HBV鎰熸煋鍙婁笌HepG2/NTCP缁嗚優缁撳悎鑳藉姏鐨勬瘮杈傸/span>


杩涗竴姝?/span>杩借釜璇ユ偅鑰呴暱杈句節骞寸殑涓村簥璧勬枡闅忚鎯呭喌锛屽彂鐜?/span>鍏朵负鎸佺画楂楬BV DNA杞介噺銆侀珮琛ㄩ潰鎶楀師浠ュ強姝e父涓欐皑閰歌浆姘ㄩ叾锛圏/span>ALT锛夋按骞颤/span>锛屽彲鍒ゆ柇涓裹/span>鈥滃厤鐤€愬彈鏈熲€濓紝浣咟/span>闅忓悗鑲濈粍缁囧娲绘缁撴灉涓轰腑閲嶅害鑲濊剰鐐庣棁鍙婄氦缁村寲锛圙2S2锛夛紝鎻愮ず宸茬粡杩涘叆鈥滃厤鐤竻闄ゆ湡鈥滭/span>銆侟/span>鐮旂┒鑰呰涓鸿鎮h€呴暱鏈熼珮鐥呮瘨杞介噺鐘舵€佷笌鐥呮瘨绐佸彉瀵艰嚧鐨勭梾姣掓劅鏌撴€у拰澶嶅埗鑳藉姏澧炲己鏈夊叧锛孅/span>骞迭/span>涓嶈兘浠h〃鐪熸鐨勫厤鐤€愬彈鐘舵€併€侟/span>鍚屾椂锛岀梾姣掍笌瀹夸富鍦ㄧ浉浜掗€夋嫨涓笉鏂繘鍖栵紝HBV鏂归潰鍙€氳繃鏀瑰彉鎰熸煋鎬х瓑缁存寔鍏舵參鎬ф寔缁劅鏌撱€傝鐮旂┒涔熸彁绀裹/span>鍙€氳繃鍦?/span>5鈥欑preS1鍖哄紩鍏ョ獊鍙楛/span>浠?/span>鎻愰珮浣撳鎰熸煋鎬э紝鏋勫缓B鍜孋鍩哄洜鍨婬BV鎰熸煋妯″瀷姣掓牚锛孅/span>鐢ㄤ簬HBV涓庡涓荤殑鐩镐簰浣滅敤銆?/span>cccDNA鐨凕/span>褰㈡垚鍜岄檷瑙e強鎶桙/span>HBV鑽墿鐨勭瓫閫夌瓑鐩稿叧鐮旂┒銆侟/span>

甯冩湕澶у/澶嶆棪澶у鍩虹鍖诲闄↑/span>绔ヨ垝骞虫暀鎺堛€佸竷鏈楀ぇ瀛︽潕绾€熸暀鎺堝拰鍗庡北鍖婚櫌寮犵户鏄庢暀鎺堜负鏈枃鍏卞悓閫氳浣滆€呫€傛潕鑿佷负璁烘枃绗竴浣滆€呫€侟/span>

 
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